Pancreatic cancer remains one of the deadliest types of cancer. The 5-year survival rate is only about 15 percent. However, thanks to the tireless efforts of researchers like Dr. Anna Silvia Wenning, important progress has been made in recent years, offering hope for more effective treatment approaches.
Dr. Wenning, what makes pancreatic cancer particularly challenging?
One of the biggest challenges is early diagnosis. Pancreatic cancer often spreads before it’s detected, and once metastasis occurs, treatment becomes significantly more difficult. Early-stage detection—before the cancer spreads—is crucial. Only then can surgery, combined with chemotherapy, offer a real chance of improving survival. Additionally, the pancreas is a particularly difficult organ from a surgical standpoint. Surgery in this area demands a highly skilled and experienced team, not only during the operation but throughout recovery as well.
Your research focuses on surgery. What exactly are you investigating?
In our “ToPanc” study, we’re analyzing the best surgical approach for tumors located in the head of the pancreas. Traditionally, part of the pancreas is removed, and the remaining tissue is connected to the stomach or small intestine. However, this procedure carries a risk of serious complications, such as leaks of aggressive pancreatic fluids into the abdominal cavity. We are evaluating whether total pancreatectomy—complete removal of the pancreas—might lead to better outcomes due to a lower risk of such complications.
Is life without a pancreas possible?
Yes, surprisingly, it is. The pancreas has two major roles: producing digestive enzymes and regulating blood sugar through insulin. Both functions can now be effectively replaced with modern medical technology. Thanks to innovations like continuous glucose monitoring and automatic insulin pumps, many patients can enjoy a quality of life compared to those who have undergone only partial removal. Ultimately, it’s about carefully weighing the risks to determine the safest and most effective therapy.
